Synthetic polymers with biological rigidity

Cell microencapsulation with synthetic polymers

The encapsulation of cells into polymeric microspheres or microcapsules has permitted the transplantation of cells into human and animal subjects without the need for immunosuppressants. Cell-based therapies use donor cells to provide sustained release of a therapeutic product, such as insulin, and have shown promise in treating a variety of diseases. Immunoisolation of these cells via microenc...

Synthetic Non-Biodegradable Polymers:

Synthetic polymers have been widely used in making various medical devices, such as disposable supplies, implants, drug delivery systems and tissue engineering scaffolds. The advantages of using polymers, as biomaterials, are their manufacturability. Polymers are easy to fabricate into various sizes and shapes compared to metals and ceramics. They are also light in weight and with a wide range ...

Nanostructures from Synthetic Genetic Polymers

Nanoscale objects of increasing complexity can be constructed from DNA or RNA. However, the scope of potential applications could be enhanced by expanding beyond the moderate chemical diversity of natural nucleic acids. Here, we explore the construction of nano-objects made entirely from alternative building blocks: synthetic genetic polymers not found in nature, also called xeno nucleic acids ...

Natural and Synthetic Biomedical Polymers

Molecular dynamics modeling the synthetic and biological polymers interactions pre-studied via docking

In previous works we reported the design, synthesis and in vitro evaluations of synthetic anionic polymers modified by alicyclic pendant groups (hydrophobic anchors), as a novel class of inhibitors of the human immunodeficiency virus type 1 (HIV-1) entry into human cells. Recently, these synthetic polymers interactions with key mediator of HIV-1 entry-fusion, the tri-helix core of the first hep...